Lobular breast cancer

Approximately 192,200 women in the United States are diagnosed annually with invasive breast cancer. (1) Conservative surgery followed by breast irradiation has replaced modified radical mastectomy as the preferred treatment for early-stage invasive breast cancer. Public education and proactive screening programs have contributed to the early detection of small tumors in a greater percentage of women. Studies have shown that women diagnosed at early stages of invasive breast cancer have equivalent outcomes when they are treated by lumpectomy and radiation therapy or modified radical mastectomy. (2-4)

Diagnosis

The diagnostic process for a breast mass begins with assessment of risk based on family history, personal history of breast problems, and physical examination. Significant signs of cancer include an irregular hard mass, lymph node involvement, and skin changes. If none of these signs is present and the mass is asymptomatic, mammography (ultrasound for women 30 years of age or less) and needle biopsy should be performed. (5)

Conservative Breast Surgery

Stage I and Stage II breast cancers are early cancers that are not fixed to the skin or muscle. If lymph nodes are involved, they are not fixed to each other or to underlying structures. Modified radical mastectomy continues to be appropriate for some patients, but breast conservation therapy is now regarded as the optimal treatment for most. Six prospective randomized trials have shown no difference in survival when mastectomy is compared with conservative surgery plus radiation for Stage I and Stage II breast cancer (Table 1). (6)

Local recurrence can happen after surgery. Following lumpectomy, local recurrence is usually at the surgical site and can be treated with mastectomy. After mastectomy, recurrence is on the chest wall. The resulting five-year survival rate is approximately 69 percent. (7)

Randomized trials also have compared breast conservation surgery alone with surgery plus radiation therapy. These trials have shown a higher recurrence rate in women who did not receive radiation. (8,9) Standard breast conservation therapy should therefore include radiation therapy.

Patient Selection

A complete history and physical examination help determine which surgery is best for each individual patient. A family history of breast cancer is not a contraindication to breast-conserving surgery. (10) Age alone should not be a determining factor in selecting surgical strategy, however elderly women may have comorbid conditions that need to be considered. A woman who is likely to have difficulty with general anesthesia might benefit from a lumpectomy performed under local anesthesia. Conversely, a woman who has difficulty complying with six weeks of radiation treatments may be a better candidate for mastectomy.

Mammographic evaluation performed within the past three months is necessary to plan surgery. The location, size, associated microcalcifications, and any other characteristics of the primary tumor must be determined. Bilateral mammography is also necessary to evaluate the presence of other suspicious lesions in the breast tissue.

Patients with invasive ductal and lobular cancers are candidates for conservative therapy if the tumor is not diffuse and negative surgical margins can be achieved. (11) The presence of positive axillary nodes is not a contraindication to breast conservation therapy. (12) Tumors located near the nipple areolar complex may require excision of the nipple, but this also is not a contraindication. (12)

The status of the margins of resection after lumpectomy is important when determining the optimal surgical treatment. When negative margins can be achieved with the preservation of adequate amounts of breast tissue, the patient is a candidate for conservative surgical therapy. If tumor remains at the margin after re-excision, modified radical mastectomy may be the treatment of choice. (13,14)

The patient's wishes should always be considered when deciding treatment. For most patients, mastectomy will not influence the likelihood of survival but may impact quality of life. Women whose breasts are preserved have fewer episodes of depression, anxiety, and insomnia. (15) A recent study of patients with early-stage breast cancer found women who undergo breast conservation therapy have improved body image, higher satisfaction with treatment, and no more fear of recurrence compared with women treated with mastectomy. (16)

Contraindications to Conservative Surgery

ABSOLUTE

When two or more primary tumors are located in different quadrants of the breast or there are associated diffuse microcalcifications which appear malignant, breast-conserving therapy is not appropriate. A woman with previous breast irradiation is also not a candidate. (17) Breast irradiation cannot be given during pregnancy, but it may be possible to perform breast-conserving surgery in the third trimester and administer irradiation after delivery. (18) As mentioned above, positive surgical margins are also an absolute contraindication.

RELATIVE

Most radiation oncologists consider a history of collagen vascular disease a relative contraindication because the poor vasculature in the skin leads to unacceptable cosmetic results. (19) Tumor size is not an absolute contraindication, but the presence of a large tumor in a small breast treated with adequate margins might result in an unwanted cosmetic appearance.

Surgical Treatment for Advanced Breast Cancer

Stage III tumors (larger than 5 cm), inflammatory cancers, and cancers fixed to the skin or muscle are usually treated with three cycles of chemotherapy followed by surgery.20 Because locally advanced cancers are more likely to spread to distant sites, systemic therapy should be commenced as early as possible.

Image-Directed Surgery

Nonpalpable carcinoma can be diagnosed using image-guided biopsy or needle localization with excisional biopsy. The image-guided biopsy uses either ultrasound or mammography to stereotactically localize the suspicious lesion. A large-bore needle is then used to obtain a sample from the lesion. This procedure is done through a small incision (several millimeters in length) with local anesthesia. A large multi-institutional study (21) of core-needle biopsies did not show seeding or spreading of cancer cells along the instrumentation track following this procedure.

The localization excisional biopsy requires that a wire be placed using mammography prior to surgery. The subsequent surgical incision is usually 1 to 2 cm in length allowing the tissue surrounding the tip of the wire to be removed.

Studies (22) suggest that the stereotactic procedure is faster and less costly than excisional biopsy. This procedure may not be possible, as in the cases of patients who cannot lie in the prone position required for the procedure, or those who have a body weight exceeding the limits of the surgery table. If the patient becomes easily agitated or is unable to stop coughing, monitored sedation and an excisional procedure are indicated.

Suspicious lesions close to the chest wall or the skin may be too difficult to remove stereotactically and may require needle localization excisional biopsy. Lesions that should probably be removed stereotactically are those in women who have breast implants or have a pacemaker implanted in the breast.

Surgical Techniques

Local anesthesia with intravenous sedation can be used for definitive excision or lumpectomy. An incision is made directly over the tumor and should be of adequate size to allow the tumor to be completely removed. The pathologist determines that the margins are grossly clear on the surgical specimen. If the surgical margin is positive on histologic evaluation, re-excision of the biopsy site is necessary to ensure complete tumor removal.

AXILLARY DISSECTION

Axillary dissection is performed under general anesthesia. The incision is transverse at the lower border of the axilla and extends to the posterior border of the pectoralis major muscle. Standard axillary dissection involves removing Level I and Level II nodes. Level II nodes lie between the pectoralis muscles, with Level III nodes above and Level I nodes below. Removal of Level III axillary nodes is necessary when obvious disease is present. A closed suction drain is placed following axillary dissection. Active range-of-motion exercises are advised beginning three to five days postoperative. Although this may prolong axillary drainage, it may prevent frozen shoulder.

SENTINEL LYMPH NODE BIOPSY